Description:

N1-methyl-pseudouridine (1-Methylpseudouridine), a methylpseudouridine, outperforms 5 mC and 5 mC/N1-methyl-pseudouridine in translation. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density.

Product Name:

N1-Me-Pseudo-UTP,100mM Solution

(N1-Me-Pseudouridine-5'-Triphosphate trisodium salt solution)

CAS No.:

1428903-59-6

Molecular Formula:

C₁₀H₁₄N₂Na₃O₁₅P₃

Molecular Weight:

564.11

Molar absorptivity:

8500 (λ=271nm)

Specification:

Appearance	Clear colorless solution
Purity(by HPLC)	≥99.0%
λmax	272nm±2nm
Concentration	100mM±3
31P NMR(D2O)	To conform structure
1H NMR(D2O)	To conform structure
pH(in buffer solution)	7.0±0.1

Storage Recommendation:

Please store in -20°C. Always avoid freeze-thaw cycles or exposure to frequent temperature changes. These fluctuations can greatly alter product stability.

Quality Control:

1. The concentration is verified by Uv-vis spectrophotometry.

2. This lot of N1-Me-Pseudo-UTP is free of DNase and RNase contamination.

3. The purity of this preparation is determined by HPLC.

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